While study abroad experiences have valuable benefits for students, computer and information science students study abroad at much lower rates than in many other disciplines. This paper presents a new study abroad course designed to increase the opportunities for computer and information science students to study abroad. “Defamiliarizing Information and Technology” (course title pseudonymized for review) supports a breadth of learning objectives in computer and information science that are specifically tailored to the global and cross-cultural context, including supporting the development of intercultural competence, examining the opportunities and pitfalls of the globalization of technology, and applying techniques of defamiliarization to the study and design of computing systems.